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Studies have shown a higher preponderance of type-1 diabetes in the Scandinavian countries [1, 49, 50]. plos. 675)\frac{5-2}{5}=0. We have improved on the model comparison, especially in the discussion part as we have already explained the differences between the models in the introduction- The differences between the fitted model coefficients (in the application) is not presented, so I am not sure the reader can appreciate what happens when a not-flexible-enough parametric form is assumed. The process of survival analytics can be explored through various techniques such as:Life tablesKaplan-Meier analysisSurvivor and hazard function ratesCox proportional hazards regression analysisParametric survival analytic modelsSurvival treesSurvival random forestThe process of survival analytics mainly depends on time and occurrence of the event.

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If the value of censoring is present, then the following steps are followed:Step1: Order the event times in ascending order of levels

t
1

t
2

t
3

t
k

. 001) than those whose mother smokes. e. Relationships between (parametric) hazard and survival curves: (a) constant hazard (e. An expert in the field could assess that conclusion. WE HAVE COMPLIED6.

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​​​​​​​​​​​​​​That’s why in Cox Regression models, the equations get a bit pop over to these guys complicated. For example, in an implanted tumor model, the researcher wishes to manipulate the immune system in some way to test if it alters survival. gov or . The following Figures 2 and 3 illustrate the event time with respect to the hazard rate. The entire customer demographic data is analyzed day to day with regard to the maintenance of business relationships, customer transactions, products purchased, and the survey that has been obtained with regards to pop over here business attractions.

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Note: Cox model serves better results than Kaplan-Meier as it is most volatile with data and features. THANK YOU. 3 years (95% CI: 4. Inversely, the hazard of type-1 diabetes was higher among frozen-thawed embryo transfer than fresh embryo transfer (aHR = 1. Please clarify in the aims that if this manuscript is a methodpaper with an application or if it is a medical paper with advanced methods.

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The logrank method is considered more robust (Hosmer and Lemeshow, 1999), but the lack of an accompanying effect size to compliment the P-value it provides is a limitation. We represent the Kaplan–Meier function by the formula:Here S(t) represents the probability that life is longer than t with ti(At least one event happened), di represents the number of events(e. Thank you. Twenty-five months after starting two subjects die. ).

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e time zero) that has been accepted in literature. – The authors said they were comparing robustness of different methods, but such comparison is not present (they only compare a FPM with 6 df and a Cox model). IT HAS BEEN EXPLAINED AS NONPARAMETRIC MAXIMUM LIKELIHOOD ESTIMATE8. When you’re ready to submit your revision, log on to https://www. Why use one against the other, if they are just a re-parametrisation of each other?Thank you.

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Cumulative distribution function. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at gro. In survival analysis the outcome is two-dimensional and defined by a survival time (with a start and an end), and an event indicator. The author(s) received no specific funding for this work.

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For instructions see:http://journals. I dont understand the notation j= 1; : : : ;P; or the notation . Please clarify. (Please upload your review as an attachment if it exceeds 20,000 characters)Reviewer #1:My general comment more the first round of reviews regarding the aim of the study still stands, but if the other reviewers and editors are happy then I have no further comments. * “Test of equality of incidence rates of type-1 diabetes” section, page 12, I would suggest reporting the rate difference per 1,000 person-years (or 100,000, as the authors prefer) to improve readability, as the currently reported rates have up to site significant digits. Cumulative event time distributionThe cumulative event time distribution for the given function

f

t

is defined in Eq.

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